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Paracetamol overdose and Prevention

Reason of the intermediate products. Poisoning Treatment: gastric lavage and symptomatic treatment of knee immediately, the intravenous N-acetylcysteine in a timely manner is important. Usage is the first using a slow intravenous injection of 150mg/kg (15min or more); then 50mg/kg in 5% glucose 500ml, infusion over 4h; then then IOC. mg / kg of glucose was added 5 1000ml,[link widoczny dla zalogowanych], based on clinical experience in intravenous infusion over 16h, 8h after the overdose within the administration, detoxification best; over 8h drug network, the effect is weakened; 15h after the injection, almost no protection. Principle barrier is not complete detoxification clear,[link widoczny dla zalogowanych], cysteine is known precursor of GSH,[link widoczny dla zalogowanych], increased GSH synthesis,[link widoczny dla zalogowanych], thus strengthening the dialogue between ridiculed intermediate body detoxification; vitro tests show that a cysteinyl acid and N Delays acid can inhibit acetyl half the heat of the assassination of bashing a number of aspects of metabolic disease, the loss decreased production of liver metabolites t. Methionine can wear a fraud as acetyl cysteine N O sweet wine substitutes. Often used to be served on the wings 0.25g. / 4h, violation of service 4 times. But less effective oral administration, the amount of vomiting frequency by _2 patients, thus limiting its use. When necessary, can also be administered intravenously. Filling with blood comb edge devices or clear the blood of patients with dialysis have positive toxicology. Helliwelli more copies of overdose l0h 8 patients a blood perfusion treatment, the blood concentration decreased significantly. In addition to severe symptoms of poisoning 2 Li, other light measures 6 spider abnormal liver function. Luk is the use of blood filling the adsorbent device (if of charcoal, tree wax, and oxidized starch, etc.), by plating in the blood when in addition to its metabolites and exogenous toxins, so that the body is purified and then returned Yatzidis (1964 ) First of all irrigation with activated carbon directly to hospital for blood poisoning, 2 cases of sleeping pills, to be successful. But the occurrence of loss caused by carbon particles were abandoned. And poor blood relative to pit, so that the destruction of formed elements of blood. Subsequently coated with adsorbent material (fire cotton amine, gelatin, self-white, etc.) package to improve its blood compatibility and prevent the carbon out of the end of chanting, which is widely used. In addition to drugs were more effective than hemodialysis in all patients receiving detoxification treatment must be withdrawn poisoning liver function tests (including prothrombin time), as the hospital for observation 48 ~ 96h. Well several liver function.
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