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Albumin microspheres after the external carotid artery distribution and degradation rate in vivo

56.3m albumin microspheres are particle size, the external carotid artery in rabbits after the detection of the average total dose of total income accounted for 98.12 to prove that the experiment to the dose and the test results into a more accurate, so that the reliability of the experiment is guaranteed. Organs in the body results in the dose is very small and will not cause damage to the organs, of which the amount of 92.239 to the entry / 6 focused on the head and neck tissues, reaching the ideal target, thus ensuring microspheres carrying the drugs on tumor cell killing of accuracy and precision of attack,[link widoczny dla zalogowanych], to ensure that the formulations in the clinical application accuracy. Microspheres generally considered too small is not safe enough, but too large microspheres (eg, greater than 300Izm above), is easy to form a collateral circulation, effects of embolization. And to 40 ~ 1O0Izm ideal size of the microspheres, their ability to peripheral vascular arterial embolization, the effect is better. Dog's carotid artery diameter of 2 ~ 8mm (average 5ram), arterioles is 10 ~ 80m (average 50m), the capillary was 4 ~ 8m (an average of 6m), and human vascular caliber closer. In this study, the size of microspheres used for the 56.3m, to micro-embolization in the peripheral arteries, in line with the requirements of embolization, the angiography results, also proved this point. Microspheres used for embolization, according to biodegradable materials are divided into classes and class 2 non-biodegradable,[link widoczny dla zalogowanych], used in this study belong to the degradation of albumin microspheres class. After the dog external carotid artery AMS, 7 ~ 9d, along with the degradation of microspheres, vascular embolization recanalization begun. Class of biodegradable microspheres that have a reliable addition to the role of embolization, it also has the following advantages: (1) microspheres in the degradation process shrinking because of their size and into smaller blood vessels and further block the blood flow; (2) degradation revascularization, is conducive to target the removal of necrotic tissue, repair and reconstruction,[link widoczny dla zalogowanych], restoring normal physiological function, for the integrated treatment of cancer surgery and radiation therapy provides an ideal organizational environment. For patients with inoperable advanced tumors, can be repeated several times embolization; (3) biodegradable microspheres of serum enzymes in the body or tissue enzymes, gradually degraded,[link widoczny dla zalogowanych], the slow release of drugs, medicines play The role of the pump. The experimental results suggest that: the average size of 56.3m of albumin microspheres used for embolization of head and neck cancer with target specific, systemic side effects,[link widoczny dla zalogowanych], biodegradable drug delivery to achieve the function, does not affect the follow-up surgery or radiation therapy and other characteristics of targeted chemotherapy for oral cancer is an ideal drug carrier.
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